About the Edith and Peter O’Donnell Award in Medicine
The Edith and Peter O’Donnell Awards were established in 2006. They are named in honor of Edith and Peter O’Donnell, who were among Texas’ most devoted advocates for excellence in scientific advancement and STEM education. The awards recognize rising star Texas researchers who are addressing the essential role that science and technology play in society and whose work meets the highest standards of exemplary professional performance, creativity and resourcefulness.
The Edith and Peter O’Donnell Award in Medicine honors Texas researchers at academic institutions in the medical field with a $25,000 honorarium, profile video and an invitation to present their research at the TAMEST Annual Conference.
Most Recent Medicine Recipient
SCLC is one of the most aggressive types of cancer. It evolves quickly and can become resistant to treatment early on, making it difficult to manage. With the current standard of care, patients generally lived around one year with the disease. Previously, all SCLC cases were treated the same; however, Dr. Byers and her team noticed that patients were responding differently to various types of treatments.
Utilizing high-throughput molecular profiling, Dr. Byers and her team identified that there are four major types of SCLC as opposed to one. This game-changing discovery led to several advances in the field, including identifying new therapeutic targets and predictive biomarkers for each type. Her team began using a patient’s blood test to understand their cancer and utilized the biomarkers present in the SCLC over time to monitor and manage their treatments.
Since SCLC evolves quickly, her team looked at the drug targets in patients’ blood samples to understand how the cancers escape from treatment. Those discoveries can inform decisions about a patient’s next treatment or combination of treatments. Further, Dr. Byers’ team can utilize these blood samples to generate new models to study and grow SCLC in the laboratory and to pinpoint the new biomarkers to match a patient with a personalized, more effective therapy option. Her work is currently showing promising results in clinical trials, with the goals of confirming more effective treatments, better engaging the immune system and improving treatment outcomes.
Past Medicine Recipients
For his groundbreaking research that has opened an entirely new field of study set to ultimately impact brain tumor patients and give potential insights into a wide range of developmental diseases.
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https://tamest.org/odonnell-awards/2024/#medicineJennifer Wargo, M.D. (NAM), MD Anderson Cancer Center | 2023
For her seminal contributions to the understanding of how the microbiome influences responses to immunotherapy and other forms of cancer treatment. Throughout her career, Dr. Wargo has advanced important research that contributed to the understanding of how best to combine targeted therapy with immunotherapy for cancer, which paved the way for several novel combination treatment approaches.
National Academy of Medicine: 2023
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Jason McLellan, Ph.D., The University of Texas at Austin | 2022
For his breakthrough research in mapping, modifying, and stabilizing coronavirus spike proteins, which paved the way for the creation of leading COVID-19 vaccines. His team of structural biologists created the first three-dimensional structure of the coronavirus spike protein, a shape-shifting protein that allows the virus to enter and infect human cells.
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Watch Dr. McLellan’s Award Acceptance >
Benjamin Arenkiel, Ph.D., Baylor College of Medicine | 2021
For his breakthrough identification of the brain’s neural pathways that are connected to eating disorders, addiction and other neuropsychiatric disorders. By understanding the makeup of neural circuits and how they talk to each other, Dr. Arenkiel’s team identified a convergent brain circuit that combines sensory perceptions and motivational state.
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Susan “Bess” Frost, Ph.D., UT Health San Antonio | 2020
For her work changing the way we look at Alzheimer’s disease. Instead of focusing on how to cure the disease, as is the focus of most Alzheimer’s research, Dr. Frost’s team looked at what causes the disease—a buildup of tau proteins inside of cells and amyloid plaques outside of it, which disrupts and eventually kills brain cell function.
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Watch Dr. Frost’s Award Acceptance >
Ralph DeBerardinis, M.D., Ph.D. (NAM), Children’s Medical Center Research Institute at UT Southwestern Medical Center | 2019
For studying how altered metabolism leads to diseases in humans. His work in cancer metabolism has changed our understanding of how tumors reprogram metabolic pathways to maximize energy production and growth.
National Academy of Medicine: 2020
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Watch Dr. DeBerardinis’ Award Acceptance >
Jordan Scott Orange, M.D., Ph.D. (NAM), Baylor College of Medicine | 2018
For defining a new class of diseases, natural killer cell deficiencies. These diseases take place when the body’s built-in defenses against infections, pathogens and cancer are defective and prevent the body from being able to adequately fight back.
National Academy of Medicine: 2018
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Watch Dr. Orange’s Award Acceptance >
Meng Wang, Ph.D., Baylor College of Medicine | 2017
For developing technology that allows us to see things we haven’t seen before in the human brain. Through his laser speckle imaging technique, we can now see blood flowing in the brain in real time, allowing us to see where clots are forming.
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Watch Dr. Wang’s Award Acceptance >
Joshua T. Mendell, M.D., Ph.D., UT Southwestern Medical Center | 2016
For pioneering work on the functions of noncoding RNAs in cancer and tissue regeneration.
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Watch Dr. Mendell’s Award Acceptance >
Thomas F. Westbrook, Ph.D., Baylor College of Medicine | 2015
For developing transformative RNAi screening technologies culminating in new therapies for patients with breast cancer and other malignancies.
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Watch Dr. Westbrook’s Award Acceptance >
Richard K. Bruick, Ph.D., UT Southwestern Medical Center | 2014
For studies on cellular responses to maintain oxygen and iron homeostasis that have helped lay the foundation for the development of small molecule therapeutics.
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Watch Dr. Bruick’s Award Acceptance >
Lora V. Hooper, Ph.D. (NAM, NAS), UT Southwestern Medical Center | 2013
For the discovery of immune mechanisms that promote host-bacterial symbiosis.
National Academy of Sciences: 2015
National Academy of Medicine: 2022
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Watch Dr. Hooper’s Award Acceptance >
Philipp E. Scherer, Ph.D., UT Southwestern Medical Center | 2012
For his innovative approaches in the area of adipocyte-derived factors have created new avenues of investigation into the causes of obesity and type 2 diabetes.
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Margaret Goodell, Ph.D. (NAM), Baylor College of Medicine | 2011
For her lab’s insights from stem cell biology to bear on the immune response to infection and the loss of epigenetic regulation in aging.
National Academy of Medicine: 2019
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Wadih Arap, M.D., Ph.D. and Renata Pasqualini, Ph.D., The University of Texas MD Anderson Cancer Center | 2010
For research leading to the first human studies showing that vascular endothelium in different tissues and cancers express unique marker molecules, accessible to circulating ligands.
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Brendan Lee, M.D., Ph.D. (NAM), Baylor College of Medicine | 2009
For identifying the mutant gene in numerous skeletal dysplasias and demonstrating that deficiency of prolyl-3-hydroxylation activity as a cause of recessive osteogenesis imperfecta.
National Academy of Medicine: 2013
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Beth C. Levine, M.D. (NAS), UT Southwestern Medical Center | 2008
For work in the field of autophagy and identification of the first mammalian autophagy gene, beclin 1.
National Academy of Sciences: 2013
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David J. Mangelsdorf, Ph.D. (NAS), UT Southwestern Medical Center | 2007
For his work on orphan nuclear receptors leading to landmark discoveries of how regulatory pathways govern cholesterol, lipid and bile acid homeostasis.
National Academy of Sciences: 2008
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Gerard Karsenty, M.D., Ph.D., (NAM), Baylor College of Medicine | 2006
For his work demonstrating that in animals, beta-blockers can reverse the course of osteoporosis.
National Academy of Medicine: 2014
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